Formestane/Lentaron CAS NO.566-48-3

Description:

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones.

It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes.

Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low.

With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity.

Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.

Applications:

1). Formestane has a very long active life on the order of 24-36 hours. You can get any sport supplement version capsules for around $40 US or less. This amount of $ will usually last you about 3-4 weeks at a sufficient dosage of 200-400mg per day. I have found 200mg a day to be perfect for on cycle anti-estrogen usage and for post-cycle recovery of natural testosterone. Formestane has zero negative feedback (even though it is an androgen by definition) and serves to elevate natural testosterone as well as any anti-estrogen/anti-aromatase drug out there, next to clomid.

2). Formestane attacks the aromatase enzyme and is therefore a first line inhibitor. So if you need immediate relief of estrogen during your cycle, you need a second class drug (estrogen receptor blocker) such as nolvadex or clomid. Formestane is a lot like arimidex in its mechanism of action in attacking the aromatase enzyme itself

3). Forma Stanzol decreases SHBG by 34% thus increasing androgen activity, which basically makes androgens/steroids in your systems MORE effective WITHOUT any increase in dosage.

4). Forma Stanzol increases IGF-1 levels by a whopping 26%. Doing so creates the perfect anabolic muscle building environment on cycle, off cycle and during pct.

Forma Stanzol decreases the number of progesterone receptors (inhibits the trenbolone and “deca-dick” type side effects and increases fat loss).

Side Effects:

The side effects which accompany Lentaron use are also those that are common to other AI drugs including fatigue, mood swings, depression, joint pain, hot flashes, headaches, swelling of the arms and legs, and high blood pressure. AIs also suppress HDL (good) cholesterol levels, and may decrease bone density increasing susceptibility to osteoporosis, fractures and breaks.

Dosage:

The most common version of formestane sold was in a topical gel form and it was dosed at 100-200mgs per application. Users would apply it onto clean, dry skin and rub in thoroughly; usually on the thighs or upper arms. It took 1 to 5 minutes to dry.

The injectable version for both breast cancer purposes and bodybuilders is 125mgs twice per week or 250mgs once per week.